Scopus Research — Dr. Hayder Kadhim Drais Al-Saadi

Interested medicinal essential oils had important role in combating various diseases, including skin and soft tissue diseases therefore the purpose of study to design, prepare and evaluate an antibacterial myrtle oil nanoemulgel and compare their efficacy against two bacterial strains, Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Nanoemulsions was prepare and pseudoternary phase diagram was constructed including three of structural components wthich are myrtle oil, polyoxyethylene (80) sorbitan monooleate and propylene glycol mixture 3:1 (w/w)% and double distilled water using the microwaves-based method. Six samples of nanoemulsion (N1-N6) were selected for characterization process and preparation nanoemulgel (G1-G6). Blank gel (G7) was also prepared to compare the antibacterial activity against G1-G6 formulations. The myrtle oil nanoemulgel (G1-G6) formulations were subjected for different evaluation. The one-way analysis of variance (ANOVA) was statistical test, where the level at (P≤0.05) was kept as significant value. The outcomes indicate that N1-N6 formulations has acceptable physicochemical features. The evaluation process for G1-G6 formulations indicate translucent, homogenous, with distinctive odor of essential oil represented by myrtle oil and no syneresis, slightly acidic pH, spreadability were (126.033 to 86.361g*cm/sec), non-Newtonian plastic flow, no skin irritation and obvious antimicrobial activity. The preparation of essential oil nanoemulsion and nanoemulgel formulations were exhibited suitable characterization, physical stability and antimicrobial activity that made it promise delivery system for treatment skin and soft tissue infection. © RJPT All right reserved.

Objectives: The increase in epidemic diseases and frequent use of alcoholic disinfectants, despite their side effects, prompt scientists to develop new sterilization products that do not contain alcoholic materials. The aim of this study was to develop, prepare, and evaluate a nanoemulgel skin sanitizer using essential oils (EOs) as active substances. Materials and Methods: A microwave-based technique was used to prepare nanoemulsion. The pseudo-ternary phase plots were constructed to contain three ingredients: EOs, polyoxyethylene (80) sorbitan monooleate, and a propylene glycol mixture (1:0:75) % (w/w) and double distilled. Five samples of nanoemulsion (NE1-NE5) were selected for the characterization and preparation of nanoemulgel (HN1-HN5). Blank gel (HN6) was also prepared to compare the antibacterial activity against HN1-HN5 formulations. Various evaluation processes were achieved for HN1-HN6 formulations. The statistical test was a One-Way analysis of variance at p ≤ 0.05 as significant data. Results: The characterization process indicates that NE1-NE5 formulations had nanosized droplets, a homogenous distribution, and an acceptable charge. The evaluation process for HN1-HN6 formulations indicates clear, homogenous, with distinctive EO odor and no phase separation, slightly acidic pH, spreadability (128.22 to 124.22 g cm/sec), plastic rheological flow, no skin lesions after application, and conspicuous antimicrobial activity. Conclusion: Laboratory characterization and evaluation demonstrated the existence of a promising product for sanitizing human skin and could be a successful alternative to alcoholic products based on the growing demand for EO products. © 2024 The Author.

Carvedilol was antihypertensive and antioxidant properties. It was practically water insoluble. It undergoes extensive hepatic first pass metabolism. The aim of this research to study permeability coefficient for NE, NLCs and LPHNs based nanogel through biological membrane using carvedilol as transdermal drug delivery system (TDDS). Aqueous phase titration, ultrasonic emulsion evaporation and microwave-based methods were used to prepare NE1-NE3, NLC1-NLC3 and LPHN1-LPHN3 respectively then subject to various measurements. The formulated lipid-based nanoparticles NE1-LPHN3 were employed as base to prepare lipid base nanogel G1-G9 that was compare to already prepared conventional gel of carvedilol (G). It was found colloidal features associated with the carvedilol loaded lipid-based nanoparticles NE1-LPHN3. The biomembrane permeation evaluation of G1-G9 formulations was indicated that the permeability coefficient (cm/min) of drug was significantly higher (p-value <0.05) for G1 and was significantly lower (p-value < 0.05) for conventional carvedilol gel (G). The preparation and evaluation processes were emphasized that G1-G9 suitable to deliver across biomembrane. The drug that was contained in LPHN based nanoglobules had lower ability to pass through experimental skin that gave it more ability to control drug diffusion in comparison to NE and NLCs. © RJPT All right reserved.

The prednisolone was very slightly soluble in water. It was a curative agent against oral recurrent aphthous stomatitis. The main objective of this study is to design, prepare, and evaluate a hybrid nanogel of prednisolone as a topical dosage form to increase prednisolone solubility, stability, and therapeutic activity. The microwave-based method prepared nine prednisolone lipid polymer hybrid nanocarriers LPHNs formulations (H1-H9). The conventional prednisolone gel (G) was prepared by solvent diffusion. The H1-H9 was evaluated thermodynamically and entered into characterization processes. The hybrid nanogels HN1-HN9 formulations were tested for various evaluations. All the H1-H9 formulations showed high thermodynamic stability and nanosized globules, low polydispersity index, acceptable surface charge, entrapment efficiency, and drug loading. The evaluation processes indicate stable organoleptic properties, high homogeneity, fair pH and spreadability coefficient values with plastic viscosity and no erythemic reaction. The profile of prednisolone release and permeability coefficient (cm/min) was significantly higher (p-value <0.05) for HN3 and significantly lower (p-value < 0.05) for conventional prednisolone gel (G). The optimized HN1-HN9 formulations were promised drug delivery systems for treating recurrent aphthous stomatitis and a wide variety of oral lesions in addition to local and transdermal delivery of various therapeutic agents and cosmetics. © 2023, Iranian Association of Pharmaceutical Scientists. All rights reserved.