Scopus Research — NEDA HASAN HUSSEIN JASIM

Background and purpose: Dopamine, 3,4-dihydroxyphenylalanine, functions as a catecholamine neurotransmitter in the brain, sending messages to other neurons to regulate information transmission to other areas of the brain, govern movement, and alter brain activity. Tyrosine undergoes an enzymatic process in the pharmaceutical industry to produce dopamine. Thus, it is crucial to measure both tyrosine and dopamine in bodily fluids simultaneously. Experimental approach: In this work, we demonstrate the production of ZnO nanoparticles using a straightforward solvothermal technique. A straightforward, quick, and sensitive electrochemical sensing platform for dopamine detection was then created using the produced ZnO nanoparticles. Key results: Cyclic voltammetry comparison revealed that the ZnO/carbon paste electrode considerably enhanced the dopamine oxidation process compared to the unmodified carbon paste electrode (CPE). With a low detection limit of 0.003 μM, the ZnO/CPE sensor's linear response for voltammetric dopamine determination was found to be between 0.01 and 480.0 μM. Conclusion: The modified CPE effectively demonstrates its great accuracy in tyrosine-induced dopamine detection. ©2025 by the authors.

Caries is the most prevalent and widespread chronic oral disease. Traditional caries filling materials, due to their lack of anti-caries capabilities, can readily develop secondary caries. Nanomaterials proposed as an effective approach for caries treatment can inhibit biofilm formation. It also can not only reduce demineralization but also promote remineralization. In recent years, nanotechnology in anti-caries materials, particularly nano-adhesive and nano-composite resin, has advanced rapidly. Because inorganic nanoparticles (NPs) interfere with bacterial metabolism and inhibit biofilm development, inorganic NPs have emerged as a new trend in dental applications. Metal and metal oxide NPs by releasing metal ions, oxidative stress induction, and non-oxidative mechanisms showed significant antimicrobial activity. For applying metal and metal oxide NPs as anti caries agents, silver, zinc, titanium, copper, and calcium ions have been shown significant attention. Moreover, fluoride functionalized inorganic NPs were also employed to improve their efficacy of them. The fluoride-functionalized NPs can promote remineralization, and inhibit demineralization by enhancing apatite formation. In this review, we have provided an overview and recent advances in the use of inorganic NPs as anti caries agents. Furthermore, their antimicrobial, remineralizing, and mechanical impacts on dental materials were discussed. © 2023 The Authors

The production of the tridentate Azo ligand 2-[2/-(benzimidazolyl)azo]-4-bromo-6-chloro phenol (BIABrClP) complexes using Co(III) and Ni(II) is discussed in this article. Spectral methods including 1H-NMR, UV-Vis, FT-IR, magnetic moment measurements, molar conductance, and elemental analysis were used to thoroughly explore the coordination mode of azo ligand containing NNO donor atoms with metal ions. The octahedral geometry for the synthesized Ni(II) and Co(III) complexes was suggested from the analytical and spectral studies. According to in vitro assays for antibacterial activity, the majority of produced compounds exhibit good action against a variety of microorganisms, including Candida albicans, Staphylococcus aureus, and Escherichia coli. © 2023 by SPC (Sami Publishing Company).

The synthesis and spectral identification of metal complex for Pd(II) ion with newfangled heterocyclic azo dye as ligand (E)-2-((4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)diazenyl)-5-iodobenzoic acid (MPIAIBA) have been organized by reaction of diazonium chloride salt solution of 2-amino-5-iodobenzoic acid with imidazole derivatives in alkaline ethanolic solution. Azo dye ligand and its Pd (II) complex have been characterized by1H-NMR, analytical data, Infrared, Mass spectrum, thermal analysis (TG-DTG), Electronic Spectral Data, molar conductance and magnetic susceptibility. The elemental investigation of the metal complexes validate the stoichiometry of the [Pd(L)Cl] type where L=azo dye ligand. Molar conductance measured results for organized Pd (II) complex showed 1:1 electrolyte for Pd (II) ion. The azo dye ligand acts a tridentate and coordinates to the palladium ion via nitrogen atom of azo group of heterocyclic imidazole ring, nitrogen atom of azo group and oxygen of carboxyl group. Square planar geometry is suggested for Pd (II) complex. In this investigation, the cytotoxicity of the azo dye ligand and its Pd(II) complex has screened for in vitro, antitumor movement against human hepatocellular carcinoma HepG-2 utilizing MTT examine. The prepared ligand and its Pd(II) complex demonstrated anticancer movement with IC50 values indicated cytotoxicity against malignant growth cell line with IC50=172.3μg/ml, WRI-68 IC50=238.6μg/ml, while Pd(II)-complex demonstrated specific cytotoxicity in contradiction of disease cell line with IC50 =115.0μg/ml; WRI-68 IC50=192.1μg/ml. The outcomes demonstrated that this sort of compounds has a significant part in the hindrance rate of the development of cells of destructive and normal lines. © RJPT All right reserved.