Scopus Research — AAMER MOUSA ALI

The popularity of stevia is high, especially among diabetics and those looking to reduce their calorie-intake. The aim of this study was to compare the effects of a commercially-available stevia and of a Stevia rebaudiana leaf extract on the liver function and histology of rats. After preparing the Stevia rebaudiana leaf extract, 60 healthy adult male rats were randomly separated into three groups: untreated control, commercial stevia treatment (25 mg/kg), and Stevia rebaudiana leaf extract treatment (25 mg/kg). Our results show that after 60 days of treatment (oral administration), a significant elevation of the alanine aminotransferase (ALT) levels was observed in the commercial stevia-treated group, suggesting potential effects on liver function. The Stevia rebaudiana leaf extract-treated group also exhibited increased ALT levels. Moreover, the aspartate aminotransferase (AST) levels were found significantly increased in both of these treatment groups (when compared to the control group). Alkaline phosphatase levels were not found altered between groups. Histological-examinations, in spite of the elevated ALT and AST levels, exhibited no abnor-malities in the liver. Although stevia is generally regarded as safe, this study underlines the importance of considering the type and form of stevia when evaluating its effects on liver health. Further study is warranted so as to elucidate the specific components and mechanisms responsible for the observed variations in liver enzymes, and to confirm the overall safety of stevia products. © 2024 by the authors.

Background: The objective was to evaluate the fPSA for discriminate between prostate cancer patients (PCa) and benign prostatic hyperplasia (BPH) depend on the variations in PSA fucosylation (Fucα1-6/3GlcNAc carbohydrates) by using Aleuria aurantia lectin (AAL) . Materials and Methods: The new method lectin-immunoassays were established for the investigation of PSA fucosylation by measuring the fluorescence of Eu(III)-chelate-labeled nanoparticles by microplate flourometer. To the identification of Fucα1-6/3GlcNAc carbohydrates on PSA surface, the lectin-immunoassays using free PSA specific monoclonal antibody as acapture and AAL coupled with Eu(III)-chelatelabeled nanoparticles using as probe for detecting fPSA . these methods compared with conventional immunoassay ELISA Result and discussion: The nanoparticle-based lectin-immunoassay method we showed a statistical significant (p < 0.001) in fPSA level depend on the fucosylation from PCa patients compared to healthy control, and also clear significant (p < 0.001) when comparing HBP patients to PCa patients but HBP compared with healthy control there is non-significant the (p=0.086) in the nanoparticle-based lectin-immunoassay methods. while in the immunoasssy ELISA was showed deffrent result . ©Advanced Scientific Research. All rights reserved

Bisphenol A is a substance for the synthesis variety of plastics, primarily epoxy resins and polycarbonates. Bisphenol can have severe effects on the type and might contribute to gradual cumulative renal injury over a lifetime. This study object to estimate toxic effect of bisphenol A on type of male mice also mitigation toxic effect of bisphenol A by using extract green tea. Healthy adult male albino laboratory mice (Mus musculus) treated for two doses of bisphenol a (20 mg/kg and 40 mg/kg body weight per day) for thirty days and green tea extract was co-administration orally as antioxidant. Biochemical parameter of serum creatinine and blood urea was calculated as indicator of kidney function. groups treated with bisphenol A showed increased in serum creatinine and blood urea also histopathological of kidney showed significant damage in groups that treated with bisphenol A whereas groups that treated with bisphenol A and co-administration green tea extract showed mitigation toxic effect of bisphenol A due to role of green tea as anti-oxidant compound. © 2009-2020, JGPT. All Rights Reserved.

The objective was to evaluate the CA125 for discriminate between epithelial ovarian cancer (EOC) and benign disease endometriosis and ovarian cyst depend on the variations in CA125 glucosylation (GlcNAc carbohydrates) by using macrophage galactose-type lectin (MGL). The new method lectin-immunoassay was established for the investigation of CA125 glucosylation by measuring the fluorescence of Eu(III)-chelate-doped nanoparticles by microplate flourometer. To the identification of GlcNAc carbohydrates on CA125 surface, the lectin-immunoassays using CA125 specific monoclonal antibody as a capture and MGL coupled with Eu(III)-chelate-labeled nanoparticles using as probe for detecting CA125. This method compared with conventional immunoassay ELISA. The concentration of antigen cancer 125 CA125 was obtained from the patients of the endometriosis, ovarian cyst and the epithelial ovarian cancer measured by the conventional immunoassay ELISA were detected a statistically significant increase (p< 0.001) with compared to the healthy control. Also in the same method, the compared CA125 levels between benign conditions of endometriosis, ovarian cyst and epithelial ovarian cancer, it was detected a statistically significant (p< 0.001) and between the same group benign conditions endometriosis with ovarian cyst also statistically significant (p= 0.005). This method depends on the immune attachment in the epitope of the secondary monoclonal antibody with tumor marker as antigen. While, new method was applied the nanoparticle-Eu dopedlectin-immunoassay, it were shown a statistically significant (p< 0.001), when compared to the epithelial ovarian cancer with endometriosis, ovarian cyst and healthy control samples. The nanoparticle-based MGL-immunoassay, this method was discriminated the CA125 sources from epithelial ovarian cancer and endometriosis. It was detected a statistically non-significant the P value were (p = 0.964) for endometriosis and (p = 0.056) for ovarian cyst when compared with healthy controls. © 2020. All Rights Reserved.

Bisphenol A (BPA) is a chemical compound have chemical formula (CH3)2C(C6H4OH)2. Bisphenol A (BPA) is use to synthesis various plastic and epoxy resin such as water bottle, many food and beverage cans, sports equipment, CDs, and DVDs. BPA could be hydrolyzed in rise temperature and basic or acidic conditions which major to leaching of BPA into drink and food containers. This study aim to evaluate toxic effect of Bisphenol A in testis of male mice and amelioration its toxic effect by co-administration of green tea extract. Healthy adult male albino laboratory mice (Mus musculus) treated with two doses of Bisphenol A (20 mg/kg and 40 mg/kg body weight per day) for thirty days. The Biochemical parameters of luteinizing hormone, testosterone and follicle stimulating hormone showed significant differences between different groups also histopathol-ogical of testis showed significant damage in groups that treat with Bisphenol A, in addition co administration of extract green tea showed significant mitigation in toxic effect of Bisphenol A. © 2019 Plant Archives. All rights reserved.

The study is aimed to evaluate the algicidal activity, antioxidant and cytotoxicity properties of the extract by ethyl acetate of algicidal bacteria Loktanella sp. Gb03 UKMGb03A (KU199217)). The algicidal activity of the ethyl acetate extract of Loktanella sp. Gb03 was assessed against toxic dinoflagellate Coolia malayensis. The cytotoxicity property was determined by MTT assay and antioxidant activity was detected by DPPH radical scavenging activity. The results of algicidal activity assay showed that the Loktanella sp. Gb03 extract possesses algicidal activity against toxic dinoflagellate Coolia malayensis. The Loktanella sp. Gb03 showed higher antioxidant activity compare to standard antioxidant ascorbic acid. In addition, Loktanella sp. Gb03 exhibited low cytotoxicity. However, the Loktanella sp. Gb03 has strong algicidal activity and antioxidant activities that are potent associated with its ethno medicinal values. © 2019 © 2019

This study involves a determination of glutamic pyruvic transaminase (GPT) and glutamic oxaloacetate transaminase (GOT) enzymes for diabetes patients. The blood samples were drawn from (32) patients and (20) volunteers as a control group. The parameters measured includes Determination of glutamic pyruvic transaminase (GPT) and glutamic oxaloacetate transaminase (GOT) enzymes. The diabetes patients were divided for two groups: The first group as (Type I diabetes). The second group as (Type II diabetes). This study included the determination of the glutamic pyruvic transaminase (GPT) levels that illustrate a low significant level for all groups of the diabetes patients compared with a group of healthy controls. The determination of the glutamic oxaloacetate transaminase (GOT) levels that significant level for all groups of the diabetes patients the approximate the control group within normal limits. © 2020. All rights reserved.