The causes of limb amputation vary worldwide according to economic, healthcare, and social conditions. In developed countries, non-traumatic lower-limb amputations are commonly associated with chronic diseases, particularly diabetes, peripheral arterial disease, and poor circulation, especially among older adults. In developing countries, traumatic injuries from road accidents, industrial and agricultural work, armed conflicts, and landmines represent major causes. Delayed diagnosis, untreated infections, and limited healthcare access further increase amputation risks, including those related to diabetes. However, these causes occur in both settings at different frequencies. Understanding these differences highlights the importance of prevention, workplace safety, early medical intervention, vascular care, rehabilitation, and access to modern prosthetic technologies.