Parasites are biological agents that may help explain certain sudden or unexplained deaths. Although they are usually associated with infectious diseases, their examination in forensic medicine can reveal pathological changes that occurred before death and help assess their contribution to the fatal outcome. Cerebral malaria provides an important example of this relationship. Infection with Plasmodium falciparum can cause severe complications and death. A published case documented malaria diagnosed only after death, highlighting the importance of considering parasitic diseases when investigating unexplained deaths, particularly in individuals who have travelled to areas where malaria occurs. The investigation combines forensic autopsy, histological examination, and appropriate laboratory testing with a review of medical records, previous symptoms, and travel history. Detecting a parasite in the body does not automatically establish it as the cause of death. Its presence must be linked to relevant pathological changes, while other possible causes are evaluated. In conclusion, collaboration among parasitologists, histologists, and forensic pathologists can improve the investigation of unexplained deaths and demonstrate the contribution of life sciences to forensic evidence