Prosthetic management of individuals with upper-extremity amputations presents all allied health professionals, including prosthetists, with a set of unique challenges. For those wearing an upper–extremity limb, the TD of the prosthesis is not covered or obscured by clothing in the same way that a lower extremity prosthesis is “hidden” by pants, socks, and shoes. By the virtue of its level, the person with upper-extremity amputation must cope with not only physical appearance changes, but the loss of some of the most complex movement patterns and functional activities of the human body. In addition, limb deficiency in the upper extremity deprives the patient of an extensive and valuable system of tactile and proprioceptive inputs that previously provided “feedback” to guide and refine functional movement. Even the simplest tasks related to grasp and release become challenging. The ability to position prosthetic limb segments in space, as well as the ability to maintain advantageous postures needed to manipulate objects, challenge the medical community to continuously improve the functional and aesthetic outcomes of prosthetic replacement for patients in this population. Many of these challenges have been addressed with new and emerging technologies. These new technologies have made it possible, in some circumstances, to successfully “fit” a patient with high-level amputation who previously would have little or no reasonable expectation to succeed with traditional technology and fitting techniques. Advanced socket interface designs and material science have afforded prosthetists the ability to offer stronger, more stable platforms for all levels of amputation, while in most cases saving substantial amounts of weight. Similarly, more innovative suspension strategies and interface mediums have increased the functional ranges of motion a patient can comfortably achieve. These advancements have had a profound and positive effect on the comfort, function, and compliance of both conventional body-powered and externally powered prostheses at all levels of amputation. Furthermore, the huge strides made in the externally powered arena have in large part been driven by these advancements and technological breakthroughs.